Autism-risk mutations reveal two opposing patterns of brain gene activity

Autism spectrum disorder (ASD) is associated with more than 1,200 risk genes, raising a fundamental question: Do these ...

Prime assembly can correct multiple mutations at once, pointing toward universal gene therapies

Genomic editing holds great potential yet continues to have limitations. Current methods either rely on untargeted gene ...

Mitochondrial DNA mutations may help turn aging hearts toward failure

Researchers at Karolinska Institutet have shown that mutations in mitochondrial DNA (mtDNA), which accumulate in many tissues ...

Calorie restriction reveals a potential way to slow age-related DNA mutations

Mutations are changes in the molecular "letters" that make up DNA, the genetic blueprint for cells. Mutations build up with ...
The American Journal of Managed Care

Aspirin's CRC Benefit Narrows to PIK3CA Exon 9/20 Mutations

ASCOLT finds no overall adjuvant aspirin benefit in colorectal cancer, but meta-analysis links improved disease-free survival ...
Phys.org

New tool allows researchers to study gene mutation directly within living human cells

Gene mutations have consequences both good and bad—from resistance to conditions like diabetes to susceptibility to certain cancers. In order to study these mutations, scientists need to introduce ...
News-Medical.Net

Caloric restriction reduces genetic mutations across the mouse genome

Mutations are changes in the molecular "letters" that make up DNA, the genetic blueprint for cells. Mutations build up with ...
Nature

The search for mutations that sperm acquire as men age

Age-related mutations give sperm-forming stem cells a selective advantage during sperm production, shaping disease risk and genetic variation in offspring. Read the paper: Sperm sequencing reveals ...

Chemotherapy alters 'Darwinian battleground' in our bodies

Cancer treatments, including chemotherapy and radiation therapy, give a growth advantage to cells with particular genetic ...